These recommendations provide a data-supported approach to establishing guidelines. They are based on the following: (1) a formal review and analysis of the recently published world literature on the topic; (2) the American College of Physicians emManual for Assessing Health Practices and Designing Practice Guidelines; (3) guideline policies including the AASLD Policy on the emDevelopment and Use of Practice Guidelines and the American Gastroenterological Association’s Policy Statement on the Use of Medical Practice Guidelines; and (4) the experience of the authors in regard to hemochromatosis.

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